Scandion Oncology CEO Newsletter autumn 2019

The Board of Directors of Scandion Oncology A/S ("Scandion Oncology" or the "Company") has prepared a prospectus (the "Prospectus") relating to the issue of new shares with preferential rights for existing shareholders of approximately SEK 236 million (the "Rights Issue"), which was resolved on by the Board of Directors on 16 November 2020, pursuant to the authorization granted by the extraordinary general meeting held on 13 November 2020. The Prospectus has today been approved by and registered with the Swedish Financial Supervisory Authority (Sw. Finansinspektionen). Today, the Company also announces the intention of changing listing venue to Nasdaq First North Growth Market Sweden.

Scandion Oncology A/S ("Scandion Oncology" or "the Company") hereby publishes the Interim Report for the period 1 January – 30 September 2020. The Interim Report is available on the Company's website (www.scandiononcology.com). Below is a summary of the report.

The press release of 16 November 2020 (released at 08:31:34) stated incorrectly that the trading in BTAs in Scandion Oncology’s rights issue starts on 3 December 2020. The correct date for the start of trading in BTAs is 26 November 2020 and the trading will be ongoing until the Danish Business Authority has registered the rights issue and BTAs are converted to shares. Below is the correct preliminary timetable for the rights issue.

The Board of Directors in Scandion Oncology A/S ("Scandion Oncology" or the "Company") has today, 16 November 2020, pursuant to the authorization granted by the extraordinary general meeting on 13 November 2020, resolved on a fully guaranteed new share issue of 10,711,848 shares with preferential rights for the Company's existing shareholders (the "Rights Issue"). The subscription price in the Rights Issue is SEK 22 per share. The Company will receive SEK 235,660,656 prior to deduction of transaction costs related to the Rights Issue.

Erroneously the Press Release from 13 November, 2020 (released at 16:46:16) was MAR labelled. In this corrected version of the Press Release the MAR label has been deleted. which was held on: Friday 13 November 2020, at 2.00 PM at Scandion Oncology A/S’ (the "Company") office at Fruebjergvej 3, 2100 Copenhagen Ø, Denmark. Due to COVID-19 it was also possible to attend the general meeting using Microsoft Teams as set out in the notice.

which was held on: Friday 13 November 2020, at 2.00 PM at Scandion Oncology A/S’ (the "Company") office at Fruebjergvej 3, 2100 Copenhagen Ø, Denmark. Due to COVID-19 it was also possible to attend the general meeting using Microsoft Teams as set out in the notice.

Scandion Oncology A/S (CVR-no. 38 61 33 91) (the "Company") Extraordinary General Meeting to be held on Friday, November 13, 2020 at 2.00 PM (CET) at the Company's address Fruebjergvej 3, DK-2100 Copenhagen Ø, Denmark. To reduce the risk of COVID-19 spreading, the Board of Directors urges shareholders to refrain from attending the Extraordinary General Meeting in person and instead cast their votes by correspondence or proxy and watch the general meeting via webcast.

Scandion Oncology A/S is pleased to announce that its second clinical study with SCO-101 has now been initiated. This phase 1B study enrolls metastatic pancreatic cancer patients who will receive SCO-101 together with 1st line standard chemotherapy (Nab-paclitaxel plus gemcitabine) in cohorts of three. The endpoints of this study are safety and efficacy, and the results are expected to be released Q2-Q3, 2021

Scandion Oncology A/S ("Scandion Oncology") today, October 9, 2020, announce that the share capital increase from the warrant exercise with the subscription period that ended last week has been registered at the Danish Companies Registration Office.

Scandion Oncology A/S ("Scandion Oncology") today announces modified timelines for the clinical Phase II colorectal cancer study and the dose range finding study for pancreatic cancer study.

On Thursday, October 1, 2020, the exercise period for Scandion Oncology A/S ("Scandion Oncology" or "the Company") warrants of series TO 1 ("TO 1") ended. A total of 2,371,455 TO 1 were exercised, corresponding to a subscription rate of approximately 99.6 percent of TO 1. Scandion Oncology is thus provided with a total of approximately MSEK 12.3 before issue costs. With this, the Company has secured capital for the continued clinical development of SCO-101.

Scandion Oncology A/S ("Scandion Oncology") today announces that the company has been selected to present the company for the MATWIN Board and investors. 

On Thursday 1 October 2020, the Extraordinary General Meeting of Scandion Oncology A/S was held. Below follows a summary of the established decisions. All decisions were taken with the required majority and in accordance with the notice of the extraordinary general meeting. 

Scandion Oncology announces that its management team and its Board of Directors have all exercised their Scandion Oncology A/S series TO 1 warrants.

Scandion Oncology A/S ("Scandion Oncology") today announces that the company has received final approval from the Danish Medicines Agency and Ethical Committee to initiate a clinical trial with the drug candidate SCO-101 in combination with first line chemotherapy in patients with inoperable or metastatic pancreatic cancer. This is the second clinical trial with SCO-101 that will commence in 2020. Results from this trial are expected in Q2-Q3, 2021

The subscription period for the series TO 1 warrants issued as part of Scandion Oncology A/S ("Scandion Oncology") rights issue conducted in June 2019 will continue until October 1, 2020. The last day for trading with the series TO 1 warrants is September 29, 2020. Holders of the series TO 1 warrants are entitled to subscribe for one new share for each warrant at a price of SEK 5.20 per share.

The Board of Directors of Scandion Oncology A/S ("Scandion Oncology" or the"Company") convenes the shareholders of Scandion Oncology to the Extraordinary General Meeting, which will be held: Thursday 1 October 2020, at 4.00 PM, at Fruebjergvej 3, 2100 Copenhagen Ø, Denmark. Due to COVID-19 the board of directors urges that no shareholder attends the general meeting physically but instead issues a power of attorney to the board of directors, vote by correspondence or participates in the general meeting through Microsoft Teams. Complete notice incl. complete proposals can be found on the website of Scandion Oncology (www.scandiononcology.com).

Scandion Oncology appoints Bo Rode Hansen as new President & CEO and co-founder Nils Brünner as new CSO to strengthen executive leadership, and secure corporate- and pipeline development towards upcoming value inflection points for Scandion Oncology.

Today, September 10th, 2020, marks the beginning of the exercise period for the warrants of series TO 1 that were issued in connection with Scandion Oncology A/S ("Scandion Oncology" or "the Company") issue of units during June 2019. The exercise period runs until and including October 1st, 2020. Upon full exercise of all warrants, Scandion Oncology will be allocated approximately SEK 12.4 million (before costs). Sedermera Fondkommission is the financial adviser and Markets & Corporate Law Nordic AB is the legal adviser in connection with the warrant exercise.

Scandion Oncology A/S ("Scandion Oncology") reports that the next evaluable colorectal cancer patient at the 8 weeks CT-scanning shows stable disease in the patients liver metastases, which are used to measure disease activity but a new metastatic lesion has appeared in the lung of the patient. According to the clinical protocol the patient will discontinue protocol treatment.

Scandion Oncology A/S ("Scandion Oncology" or the "Company") hereby publishes the Half-Year Report for the period 1 January – 30 June 2020. The Half-Year Report is available on the Company's website (www.scandiononcology.com). Below is a summary of the report.

Scandion Oncology A/S ("Scandion Oncology") announces that Saniona has reduced its ownership stake in Scandion Oncology A/S to below 10%. Saniona, together with CEO Nils Brünner and CSO Jan Stenvang initially founded Scandion Oncology A/S in 2017. After the last capital raise in June 2019, Saniona owned approximately 18% of Scandion Oncology. Proceeds from sales of shares will be used to continue Saniona’s advancement of their pipeline, including mid/late-stage clinical trials with Tesomet.

Scandion Oncology A/S ("Scandion Oncology") reports on data from the first cohort of chemotherapy resistant colorectal cancer patients treated with SCO-101 and chemotherapy (FOLFIRI). All patients in the first cohort have now completed at least one treatment cycle (14 days). The main result is that 150 mg daily oral SCO-101 potentiates the effects of chemotherapy (FOLFIRI). Based on the safety data from this first cohort of patients, the Data Safety Monitoring Board has recommended to include 3 additional patients at 150 mg SCO-101 in order to get more details on the interactions between SCO-101 and FOLFIRI.

Scandion Oncology A/S ("Scandion Oncology") announces that the results from the 4 SCO-101 phase I clinical trials have been published (https://doi.org/10.1111/bcpt.13466) in the International peer-reviewed journal" Basic & Clinical Pharmacology & Toxicology".

Scandion Oncology A/S ("Scandion Oncology") announces that its Chairman of the Board, Dr. Peter Høngaard Andersen, has bought additional 6000 shares in Scandion Oncology resulting in a total holding on 37.839 shares in the Company.

Scandion Oncology A/S ("Scandion Oncology") announces that its two co-founders, CEO Nils Brünner and CSO Jan Stenvang, have extended the lock-up period for their Scandion Oncology shares with an additional three months (until October 1, 2020). In total, the lock-up agreements correspond to approximately 13 percent of the votes and capital in Scandion Oncology.

Scandion Oncology A/S ("Scandion Oncology") announces that Saniona has reduced its ownership stake in Scandion Oncology A/S to below 15%. Saniona, together with CEO Nils Brünner and CSO Jan Stenvang initially founded Scandion Oncology A/S in 2017. After the last capital raise in June 2019, Saniona owned approximately 18% of Scandion Oncology. Proceeds from sales of shares will be used to continue Saniona’s advancement of their pipeline, including mid/late-stage clinical trials with Tesomet.

Scandion Oncology A/S ("Scandion Oncology") is pleased to announce that it has received EURO 800,000 to be used together with Erasmus University Medical Centre, Rotterdam, the Netherlands, to study the Mechanism of Action of SCO-101 in reversing resistance to antiestrogens in breast cancer. Moreover, the grant will be used to initiate a phase Ib study with SCO-101 in women with antiestrogen-resistant breast cancer. In order to optimize the recruitment of patients to the clinical study, the Swedish/Danish Biotech Company 2cureX AB will use their proprietary IndiTreat test to select those patients with the highest likelihood of responding to SCO-101.

Scandion Oncology A/S ("Scandion Oncology") is pleased to announce that a Clinical Trial Application (CTA) has been submitted to the Danish Medicines Agency and the Ethical Committee. A response is expected within 60 days.   

Lund, Sweden, June 4, 2020 – Alligator Bioscience (Nasdaq Stockholm: ATORX) and Scandion Oncology (Spotlight, Sweden: SCOL), today announced signing of a collaboration agreement. The two companies have agreed to explore the anti-tumor efficacy of the CD40 antibody mitazalimab (Alligator Bioscience) in combination with SCO-101 (Scandion Oncology) as an addition to chemotherapy in resistant preclinical tumor models. The expectation is that SCO-101 will revert chemotherapy resistance and thereby further strengthening the anti-tumor effects of mitazalimab. 

On May 27th, 2020, the Annual General Meeting of Scandion Oncology A/S ("Scandion Oncology" or the "Company") was held. Below follows a summary of the established decisions. All decisions were taken with the required majority.

Scandion Oncology A/S ("Scandion Oncology") is pleased to announce that the first patient has received treatment with SCO-101 and FOLFIRI with no unexpected SCO-101-related events observed. By measuring an exposure biomarker during treatment, it was observed that SCO-101 caused the expected changes in the level of this exposure biomarker, demonstrating that SCO-101 was present in the body in an effective concentration. 

Scandion Oncology A/S ("Scandion Oncology" or "the Company") hereby publishes the interim report for the period January – March 2020. The interim report is available on the Company's website (www.scandiononcology.com). Below is a summary of the report.

Scandion Oncology has received positive results on the antibiotic in vivo effects of SOM-001 and has decided to proceed with preclinical testing.

The Board of Directors of Scandion Oncology A/S ("Scandion Oncology" or the"Company") convenes the shareholders of Scandion Oncology to the Annual General Meeting, which will be held: Wedensday 27 May 2020, at 4.00 PM at the offices of the Company, Fruebjergvej 3, 2100 København, Denmark. Due to COVID-19 the Board of Directors urges that no shareholder attends the general meeting physically but instead issues a power of attorney to the Board of Directors, vote by correspondence or participates in the general meeting through Microsoft Teams. See further details at the end of this notice.

Scandion Oncology A/S ("Scandion Oncology") hereby publishes the Annual Report for 2019. The Annual Report 2019 is available on the company's website (www.scandiononcology.com).

On April 27th CMO Peter Michael Vestlev will present at the AACR Virtual Annual Meeting. The presentation is a 5 minutes video entitled "Clinical phase II study of SCO-101 - an inhibitor of SRPK1 and ABCG2 - restoring sensitivity to FOLFIRI in metastatic FOLFIRI resistant colorectal cancer patients"

  Dear Scandion Oncology shareholder, Scandion Oncology wants to thank you for your continued trust and confidence in us and our work as we work through these challenging times together, and we hope that you and your families are safe and healthy. With the widening spread of COVID-19 across the world, we wanted to provide you with the latest updates on our activities, and, just as important, emphasize our continued commitment to bringing our drugs to the many cancer patients with untreatable drug resistant cancer disease.

Scandion Oncology A/S ("Scandion Oncology") has published that combining SCO-101 and the chemotherapy drug docetaxel, which is used in the treatment of several types of cancer, results in synergy. Based on modelling of preclinical data with docetaxel resistant cancer cells, Scandion Oncology has published that SCO-101 significantly increases the potency of docetaxel (docetaxel belongs to the group of taxane chemotherapy). Furthermore, the results provided key information regarding promising dose ratios and dose levels for future clinical studies when using  the combination of SCO-101 and taxanes.

The current Phase II clinical study with SCO-101 is treating a serious diseases with no satisfactory treatment option and therefore Scandion Oncology has together with its clinical partners at the hospitals decided to continue the colorectal cancer study with FOLFIRI resistant patients. Due to the current situation related to the COVID-19 pandemic, Scandion Oncology is not able to predict how many patients that will be included in the next couple of months. Enrolment into the study will be solely based on the discretion of the clinical investigators.

Scandion Oncology A/S ("Scandion Oncology") hereby announces that the company has been informed by the State Serum Institute in Copenhagen that conducts the animal experiments with the antibiotic-resistant bacteria and the Scandion Oncology compounds, that due to the coronavirus, the State Serum Institute must postpone the last of three animal studies until the coronavirus situation is under control. Scandion Oncology estimates that the final data will be published during April-May 2020 instead of March 2020.

Scandion Oncology A/S ("Scandion Oncology" or "the Company") today announces that the Chairman, Vice Chairman and Chief Medical Officer of the Company have bought shares in Scandion Oncology. The shares have been acquired in the daily trading on Spotlight Stock Market.

Scandion Oncology A/S ("Scandion Oncology") informs about a short delay in the clinical phase II study with SCO-101 in drug resistant colorectal cancer. The delay is due to external events outside the influence of Scandion Oncology and is unrelated to the treatment with SCO-101.

Scandion Oncology A/S ("Scandion Oncology") hereby announces that the company has published pre-clinical results with its second drug candidate, SCO-201, for reversal of drug resistance.

Scandion Oncology A/S ("Scandion Oncology" or "the Company") hereby publishes the year-end report for the period January - December 2019. The year-end report is available on the Company's website (www.scandiononcology.com). Below is a summary of the report.

Scandion Oncology A/S ("Scandion Oncology") hereby announces that the company has obtained DKK 5 million from Innovation Fund Denmark for the clinical development of SCO-101 in metastatic pancreatic cancer.

The clinical Phase II trial with drug resistant metastatic colorectal cancer patients has now been registered at ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT04247256?term=scandion+oncology&draw=2&rank=1).

CEO Nils Brünner and Chairman of the Board Peter Høngaard, have now safely returned from the JP Morgan Meeting in San Francisco. The JP Morgan meeting is the largest meeting in the world when it comes to meeting potential partners within Life Science. Prior to the meeting, Scandion Oncology had arranged face-to-face meetings with pharma companies, investors, bankers and service providers.

Scandion Oncology A/S ("Scandion Oncology") Chief Executive Officer Nils Brünner and Chairman of the Board Peter Høngaard will be attending the JP Morgan 38th Annual Healthcare Conference 13-16 January 2020 in San Francisco.

Scandion Oncology A/S ("Scandion Oncology") today announces that the company has received approval from the Ethics Committee regarding its first clinical trial for SCO-101 at hospitals in Denmark. The only change that the Ethics Committee requested was to include a one-page summary of the patient information sheet for review before the study could be started.  With this approval, Scandion Oncology follows its objectives.

Scandion Oncology A/S (“Scandion Oncology”) today announces that the company has identified novel analogues with more than tenfold higher potency against antibiotic resistant bacteria and that the in vivo animal study has been delayed from Q4 2019 until Q1 2020 due to technical issues with the control substance. This will not affect the company"s goal of finding a partner for commercializing Scandion Oncology’s drug candidate SOM-001 and analogs for antibiotic resistance in 2020. Moreover, it will not affect the company’s cash position.

Scandion Oncology A/S ("Scandion Oncology" or "the Company") today announces that the Chairman and Vice Chairman of the Company buy shares in Scandion Oncology. The shares come from a prior transaction where the CEO and CSO of Scandion Oncology bought shares from the former CEO. Below is a detailed description of the transactions being conducted. All transactions are intended to be done outside the market.

Scandion Oncology A/S (“Scandion Oncology”) today announces that the company has received final approval from the Danish Medicines Agency for start of a clinical Phase II trial with the drug candidate SCO-101 in combination with chemotherapy in patients with drug resistant metastatic colorectal cancer. The study is conducted in two parts. The first interim results from this first part   are expected in Q2 2020 and the final study is expected to be available by the end of 2020.

Dear Scandion Oncology shareholder,Being able to change drug resistance will have impact on millions of cancer patients world-wide. With the current speed of development and if everything works out, we expect to start the clinical phase II study with SCO-101 treatment by December 2019. In this newsletter, I will give a short summary of what’s to come for SCO-101, with a primary focus on the upcoming phase II clinical trial.

Scandion Oncology A/S (”Scandion Oncology” or the “Company”) hereby publishes the InterimReport for the period 1 January – 30 September 2019. The Interim Report is available on theCompany"s website (www.scandiononcology.com). Below is a summary of the report.

Scandion Oncology A/S (“Scandion Oncology”) today announces that the European Patent Office (“EPO”) has granted the company’s patent application for SCO-101 when combined with chemotherapy. Patent is valid until May 2037.

Scandion Oncology A/S (“Scandion Oncology”) today announces that the company has submitted an application to the Danish Medicines Agency for permission to conduct a clinical Phase II study in patients with metastatic colorectal cancer. Scandion Oncology is thus following the timelines presented in the prospect. The study will be initiated at hospitals in Denmark. The clinical Phase II study will be conducted in two parts, and provided that the study is approved in the fourth quarter of 2019, the first data are expected in Q2 2020 and the final study report will be released in H1 2021.

Scandion Oncology A/S (“Scandion Oncology”) today announces that the report on the in vivo animal data on antibiotic resistance SOM-001 is extended until mid-Q4 2019 due to shortage in slots at the provider. This will not affect the company"s goal of finding an overall strategy for commercializing SOM-001 in 2020.

Scandion Oncology A/S (“Scandion Oncology”) today announces that Peter Høngaard has accepted to take the role of Chairman of the Board as of October 1, 2019. With Peter Høngaard’s strong knowledge of developing life science businesses from research to commercialization Scandion Oncology is now taking full advantage of this added expertise in the Board. The current Chairman Jørgen Bardenfleth will now take the role of Vice-Chairman.

Dear Scandion Oncology shareholder, Scandion Oncology is heading towards an exciting future where we will, hopefully, deliver a new cancer treatment to the market. One that can help overcome chemotherapy resistance - an accomplishment that truly would mark a new dawn for modern cancer treatment.

Scandion Oncology A/S (”Scandion Oncology”) hereby announces that, in connection with the registration of the new share issue carried out during the second quarter 2019, the main shareholders ownership in Scandion Oncology has decreased.

Scandion Oncology A/S (”Scandion Oncology” or the “Company”) hereby publishes the Half-Year Report for the period 1 January – 30 June 2019. The Half-Year Report is available on the Company"s website (www.scandiononcology.com). Below is a summary of the report.

Scandion Oncology wishes to make aware that we have published a new Q&A on August 20, 2019. The Q&A concerns the status on a EU grant regarding endocrine treatment of breast cancer cell lines. The Q&A can be read here: https://scandiononcology.com/qa/

In June/July 2019, Scandion Oncology A/S (“Scandion Oncology”) conducted a rights issue of units in which the general public was given the opportunity to subscribe. Through the rights issue, a total of 7,144,590 shares and 2,381,530 warrants of series TO 1 were issued. First day of trading in TO 1, ISIN DK0061144078, will be on Thursday, 8 August 2019.

In June/July 2019, Scandion Oncology A/S (“Scandion Oncology”) conducted a rights issue of units in which the general public was given the opportunity to subscribe. Through the rights issue, a total of 7,144,590 shares and 2,381,530 warrants of series TO 1 were issued. The rights issue of units has now been fully registered at the Danish Business Authority. Last day of trading in BTU (paid-up for units) will be on July 30, 2019 and the stop date will be on August 1, 2019.

On July 9, 2019, the subscription period in Scandion Oncology A/S’s ("Scandion Oncology") rights issue of units ended. The interest in the rights issue was significant and the rights issue was subscribed to a total of approx. SEK 58.3 million (excl. guarantee commitments), corresponding to a subscription rate of approx. 199 percent. Through the rights issue, a total of 7,144,590 shares and 2,381,530 warrants of series TO 1 will be issued and Scandion Oncology will now be provided approx. SEK 29.3 million before issue costs. Settlement notes are expected to be sent out today, July 12, 2019. Sedermera Fondkommission is the financial advisor in connection with the rights issue and Markets & Corporate Law acts as the legal advisor.

Scandion Oncology A/S (“Scandion Oncology” or the “Company”) today announces that the Company has identified the four clinical sites where the lead candidate drug SCO–101 will be tested in combination with chemotherapy in patients with metastatic and drug resistant colorectal cancer. The first patients to enter the trial are expected to be included in December 2019. The four sites are located in Denmark in the Capital Region, Region South, Region North and Region Zealand.

Scandion Oncology A/S (”Scandion”) today announced that SCO-101 tablets have successfully been produced as a pilot production by Solural Pharma Aps, Denmark (“Solural”). Scandion is thus following the timelines for SCO-101’s clinical development. The SCO-101 raw material is produced by Cambrex in Sweden and then transferred to Solural in Denmark where it is formulated into tablets. Scandion expects to initiate its first clinical Phase II study with SCO-101 in patients with drug resistant cancer in late 2019.

Today, on the 20th of June, 2019, the subscription period for Scandion Oncology A/S ("Scandion Oncology") rights issue begins. The subscription period runs until the 9th of July 2019. A fully subscribed issue of units will initially provide Scandion Oncology with approximately MSEK 29.3 and an additional approximately MSEK 12.4 (before issue costs) in a later stage if all consideration free warrants are exercised. Ahead of the rights issue, Scandion Oncology has received subscription commitments from, among others, senior executives and board members and also entered into agreements regarding top-down guarantee. In total, the subscription commitments and the top-down guarantees corresponds to approx. 89 percent of the inital issue volume. Prospectus, teaser and subscription forms are available through the websites of Scandion Oncology (www.scandiononcology.com) and Sedermera Fondkommission (www.sedermera.se). The investment documents are also available via Spotlight’s website (www.spotlightstockmarket.com). Subscription of units can be made by submitting a subscription form to Sedermera Fondkommission or through their website (via BankID). 

Prospectus relating to the rights issue in Scandion Oncology A/S (”Scandion Oncology” or ”the Company”) has been approved and registered by the Danish Financial Supervisory Authority and is now available at Scandion Oncology’s website (www.scandiononcology.com), Sedermera Fondkommission (www.sedermera.se) and at the website of Spotlight Stock Market (www.spotlightstockmarket.com). Teaser and subscription form will be published on the webpages mentioned above at the start of the subscription period. The prospectus has also been passported to Sweden.

On June 11th, 2019, the Extraordinary General Meeting of Scandion Oncology A/S (”Scandion Oncology” or the ”Company”) was held. Below follows a summary of the established decisions. All decisions were taken with the required majority. 

Scandion Oncology A/S (“Scandion Oncology”) hereby announces that Jørgen Bardenfleth will continue as Chairman of the Board and Peter Høngaard Andersen will take over the position as Vice-Chairman of the Board.

In connection with the announcement that the Board of Directors of Scandion Oncology A/S (“Scandion Oncology”) has proposed to an Extraordinary General Meeting to conduct an issue of units, main shareholders, Board of Directors and management of Scandion Oncology have signed and prolonged so-called lock-up agreements, which means that they commit to retain 90 percent of their holdings in the company over the upcoming 12 months calculated from June 2019. In total, the lock-up agreements correspond to 53 percent of the share of votes and capital in Scandion Oncology. The following parties have entered into lock-up agreements:

On May 29th, 2019, the Annual General Meeting of Scandion Oncology A/S (”Scandion Oncology” or the“Company”) was held. Below follows a summary of the established decisions. All decisions were taken with the required majority. 

The Board of Directors of Scandion Oncology A/S (”Scandion Oncology” or the “Company”) convenes the shareholders of Scandion Oncology to an Extraordinary General Meeting, which will be held: Tuesday, June 11, 2019 at 11:00 AM, Fruebjergvej 3, 2100 København, Denmark

Scandion Oncology A/S (“Scandion Oncology” or ”the Company”) today announces that the Board of Directors has proposed to an Extraordinary General Meeting to conduct an issue of units that can provide a maximum of approximately SEK 41.7 million to the Company before issue costs. The capitalization consists of shares amounting to a maximum of approximately SEK 29.3 million and consideration free warrants of series TO 1 that can additionally provide the Company with a maximum of approximately SEK 12.4 million, provided the warrants are fully exercised. The public is also invited to subscribe for units in the rights issue. Scandion Oncology has in advance received pre-subscriptions and “top-down” guarantee commitments from institutional and private investors totaling approximately 82 percent of the issue volume. Notice of Extraordinary General Meeting will be published shortly.

Scandion Oncology A/S (”Scandion Oncology” or ”the Company”) hereby publishes the Interim report for the period 1 January – 31 March 2019. The interim report is available on the Company"s website (www.scandiononcology.com). Below is a summary of the report.

Scandion Oncology A/S would like to make use of the full window for releasing the Q1 2019-report. The company therefore releases the Q1 2019-report on May 27, 2019. The previously reported reporting date was May 23, 2019.

SCANDION ONCOLOGY A/S is pleased to announce that the company has received an “Intention to Grant” notice from the EPO regarding its European patent application 17726573.3, which includes SCO-101 in combination with specific topoisomerase I inhibitors to treat various cancers. The patent will last until 2037.

The Board of Directors of Scandion Oncology A/S (”Scandion Oncology” or the“Company”) convenes the shareholders of Scandion Oncology to the Annual General Meeting, which will be held: Wednesday, May 29, 2019 at 16:00 PM. Fruebjergvej 3, 2100 København Complete notice incl. complete proposals from the Board and appendices can be found on the website of Scandion Oncology (www.scandiononcology.com).

Scandion Oncology A/S hereby publishes the Annual Report for 2018. The Annual Report 2018 is available on the company"s website (www.scandiononcology.com).

Scandion Oncology A/S (”Scandion” or ”the Company”) announces today that the Company has signed a collaboration agreement with Department of Drug Design and Pharmacology, University of Copenhagen regarding development of a class of drugs that can revert anti-cancer drug resistance. The lead compound from this drug class, named SCO-301, complements Scandion’s drug portfolio, since it targets resistance against a large class of anti-cancer drugs that is not targeted by SCO-101 or SCO-201. Scandion has thus already fulfilled one of the milestones for 2020.

Scandion Oncology A/S (”Scandion” or ”the Company”) announces today that the Company has obtained a SME Instrument phase I grant from EU.

Scandion Oncology and The Danish Medicines Agency have had a very positive and constructive meeting, where Scandion Oncology’s plans for the upcoming clinical phase II study of SCO-101, in combination with chemotherapy in patients with drug resistant metastatic cancer study, were discussed.  The Danish Medicines Agency has confirmed that no further non-clinical studies are required to initiate the planned phase II clinical study, and only minor comments were given to the dosing schedule of SCO-101 proposed by Scandion Oncology.

Scandion Oncology A/S and Solural Pharma ApS have entered into an agreement regarding manufacturing of SCO-101 tablets for clinical phase II trials with drug-resistant cancer patients. Scandion Oncology will soon be completing the validation and substance production of SCO-101 at Cambrex, Sweden. Next step will be to initiate production of tablets. Scandion Oncology has employed an experienced team of drug production specialists. The team has previously been involved in the original production and formulation of SCO-101 in the four completed phase I studies. Saniona, the main shareholder in Scandion Oncology, recently performed a legally required audit of Solural Pharma. This audit is valid and usable for Scandion Oncology. The manufacturing of SCO-101 tablets is in accordance with Scandion Oncology’s plans and targets for 2019.

Scandion Oncology A/S (Scandion Oncology) hereby announces that Scandion Oncology, together with University of Copenhagen, has discovered that a number of Scandion Oncology’s compounds are able to overcome antibiotic resistance in bacterial infections through a new mechanism of action. These are findings from preclinical studies. The discovery may pave the way for new drugs for treatment of antibiotic resistance. Scandion Oncology has filed a patent application and owns all rights to this invention. Scandion Oncology is currently exploring the commercial opportunities for these novel findings, since the market for these types of drugs is significant. The outcome of the exploration of the commercial opportunities will weigh in on Scandion Oncology’s decision on how the indication should be further advanced. Scandion Oncology continues to have a strict focus on drug resistance in oncology, but sees this new discovery as a very interesting complement to the Scandion Oncology portfolio. Presently, the Scandion Oncology efforts within antibiotic resistance only requires small-scale resources.

Scandion Oncology A/S (”Scandion Oncology” or ”the Company”) hereby publishes the year-end report for the period January - December 2018. The year-end report is available on the Company"s website (www.scandiononcology.com). Below is a summary of the report.

Scandion Oncology A/S ("Scandion Oncology") today announces that the Chairman of the Board Jørgen Bardenfleth and Board member Carl Borrebaeck acquire shares from CEO Nils Brünner and CSO Jan Stenvang. Moreover, Nils Brünner and Jan Stenvang acquire shares from former CEO Kim Arvid Nielsen. Below is a description of the transactions. All transactions are done outside the market.

Scandion Oncology A/S (“Scandion Oncology”) today announces that the company has selected Radboud University Medical Centre in Nijmegen, the Netherlands, as collaborator for the Boost4Health internationalisation voucher. As previously announced this grant amounts to EUR 14,999. Scandion Oncology received additionally EUR 5,000 from the Boost4Healths program (Product Validation voucher). The scientific collaboration concerns the use of SCO-101 to revert resistance to anti-estrogen treatment in patients with advanced breast cancer.

Scandion Oncology A/S (”Scandion Oncology”) herby reports interim report for Q3 2018.

Scandion Oncology A/S has been granted an Impact Voucher of 14.999 EUR from Biopeople, Denmark’s Life Science Cluster, as partner in the Boost4Health Interreg project of leading bioregions in North-West Europe. The Impact Voucher supports SCO-101 development in relation to anti-estrogen resistance in breast cancer. The selection committee of Boost4Health based their decision on the benefit of providing access to European partners and markets and to the advancement of product validation for Scandion Oncology A/S.

Today, November 8, 2018, is the first day of trading in Scandion Oncology A/S’s (“Scandion Oncology”) shares on Spotlight Stock Market. The share is traded under the ticker SCOL and ISIN code DK0061031895.

Första handelsdag på Spotlight Stock Market för Scandion Oncology A/S aktie är den 8 november 2018. Kortnamnet för aktien är SCOL.

On October 18, 2018, the subscription period for Scandion Oncology A/S’s ("Scandion Oncology") new share issue of approx. SEK 26 million prior to listing on Spotlight Stock Market (“Spotlight”) was completed. Scandion Oncology received subscription for a total of approx. SEK 104.7 million, including presubscription commitments, from a total of 74 pre-subscribers. This corresponds to a total subscription ratio of approx. 402.7 percent. Through the new share issue, Scandion Oncology will receive approx. 1 500 new shareholders. Settlement notes are scheduled to be sent to all allotted shareholders today.

Today, October 4, 2018, the subscription period for Scandion Oncology A/S ("Scandion Oncology") new share issue begins, prior to planned listing on Spotlight Stock Market. The subscription period expires on October 18, 2018. With a fully subscribed new share issue, the company will receive a maximum of approximately SEK 26 million before issue costs. The company has secured pre-subscriptions of approximately SEK 18.5 million, corresponding to approximately 71 percent of the planned issue amount. Memorandum, teaser and subscription forms are available through the websites of Scandion Oncology (www.scandiononcology.com) and Sedermera Fondkommission (www.sedermera.se). The investment documents are also available via Spotlight’s website (www.spotlightstockmarket.com). Subscription of shares can be made by submitting a subscription form to Sedermera Fondkommission or through their website (via BankID) or Nordnet Bank (www.nordnet.se). For subscription of shares directly through other banks, the subscriber is asked to contact his or her bank.

Idag, den 4 oktober 2018, inleds teckningstiden i Scandion Oncology A/S ("Scandion Oncology") nyemission inför planerad notering på Spotlight Stock Market (”Spotlight”). Teckningstiden löper till och med den 18 oktober 2018. Vid fulltecknad nyemission tillförs bolaget högst cirka 26 MSEK före emissionskostnader. Bolaget har på förhand via teckningsförbindelser skriftligen avtalat om cirka 18,5 MSEK, motsvarande cirka 71 procent av emissionsvolymen. Memorandum, teaser och anmälningssedel finns tillgängliga på Scandion Oncologys (www.scandiononcology.com) och Sedermera Fondkommissions (www.sedermera.se). Investeringsdokumenten finns även tillgängliga via Spotlights hemsida (www.spotlightstockmarket.com). Teckning av aktier kan göras genom insändande av anmälningssedel till Sedermera Fondkommission eller via Sedermeras hemsida (genom BankID) alternativt Nordnet Bank (www.nordnet.se). För teckning av aktier direkt genom övriga banker ombedes tecknaren att kontakta sin bank.

Today, Scandion Oncology A/S (“Scandion Oncology”) announces that the company has been approved for listing at Spotlight Stock Market (”Spotlight”). The approval is given under the condition that the company raises the minimum limit and that the company obtains a sufficient number of shareholders in accordance with Spotlight’s listing agreement in the upcoming IPO. The company plans to raise approximately 26 MSEK and the subscription period will run from October 4, 2018, to October 18, 2018, both dates inclusive. The company has secured pre-subscription of 18.5 MSEK, corresponding to approximately 71 percent of the planned issue amount.

Scandion Oncology A/S (“Scandion Oncology”) meddelar idag, den 1 oktober 2018, att bolaget har godkänts för notering på Spotlight Stock Market (“Spotlight”) förutsatt att lägsta gränsen i bolagets kommande nyemission uppnås samt att marknadsplatsens ägarspridningskrav uppnås. Bolaget meddelar även att teckningstiden för nyemissionen om cirka 26 MSEK inleds den 4 oktober 2018 och pågår till och med den 18 oktober 2018. Bolaget har på förhand via teckningsförbindelser skriftligen avtalat om 18,5 MSEK, motsvarande cirka 71 procent av emissionsvolymen.